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pentobarbital will minimize the level or effect of parecoxib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown.pentobarbital will lessen the level or impact of disopyramide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Mysterious.Contraindicated. Coadministration of doravirine with